Age differences in periventricular and deep white matter lesions

Relationship between periventricular or deep white matter lesions and arterial elasticity indices in very old people.

OBJECTIVE To examine the relationship between the presence of cerebral white matter lesions and large and small artery elasticity indices in a population of healthy, very old subjects. METHODS We studied 24 subjects (14 women, 10 men) with a mean age of 84+/-5 years, who were free from overt neurological, cardiovascular or psychiatric illness. We measured blood pressure and heart rate in supi...

Should we distinguish between periventricular and deep white matter hyperintensities?

Periventricular and Deep White Matter Hyperintensities? To the Editor: The recent article by DeCarli et al1 addresses a somewhat neglected aspect of white matter hyperintensities (WMH), the significance of their anatomical location. The authors argue that the commonly accepted categorization into deep (DWMH) and periventricular (PVWMH) WMH is arbitrary, because the 2 are very highly correlated,...

Periventricular cerebral white matter lesions predict rate of cognitive decline.

The prospect of declining cognitive functions is a major fear for many elderly persons. Cerebral white matter lesions, as commonly found with magnetic resonance imaging, have been associated with cognitive dysfunction in cross-sectional studies. Only a few longitudinal studies using small cohorts confirmed these findings. We examined the relation between severity of white matter lesions and cog...

Significance of age-related white matter lesions.

Diastolic carotid artery wall shear stress is associated with cerebral infarcts and periventricular white matter lesions.

BACKGROUND AND PURPOSE Low wall shear stress (WSS) is an early marker in the development of vascular lesions. The present study aims to assess the relationship between diastolic and systolic WSS in the internal carotid artery and periventricular (PWML), deep white matter lesions, and cerebral infarcts (CI). METHODS Early, mid, and late diastolic and peak systolic WSS were derived from shear r...